1,331 results found
    1. Neuroscience

    Mechanical overstimulation causes acute injury and synapse loss followed by fast recovery in lateral-line neuromasts of larval zebrafish

    Melanie Holmgren, Michael E Ravicz ... Lavinia Sheets
    Mechanically induced injury of zebrafish lateral-line organs shares key features of damage observed in noise-exposed mammalian ears, such as inflammation and synapse loss, yet, unlike mammals, rapidly repairs following damage.
    1. Evolutionary Biology

    Wings and halteres act as coupled dual oscillators in flies

    Tanvi Deora, Siddharth S Sane, Sanjay P Sane
    Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
    1. Cell Biology

    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

    Justin Krish Williams, Jordan Matthew Ngo ... Randy Schekman
    Plasma membrane damage causes the release of exosomes from cultured human cells.
    1. Cell Biology

    Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis

    Blair W Benham-Pyle, Joo Yong Sim ... William James Nelson
    Mechanicals forces and local (Wnt) signaling can synergize to increase β-catenin signaling and produce unique growth phenotypes.
    1. Cell Biology
    2. Neuroscience

    Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

    Michael Krieg, Jan Stühmer ... Miriam B Goodman
    A conceptual framework and physical model shows how actin-spectrin networks and microtubule bundles can protect axons from mechanical stress.
    1. Cell Biology

    Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration

    Alexandra M Fister, Adam Horn ... Anna Huttenlocher
    Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.
    1. Cell Biology

    Meisosomes, folded membrane microdomains between the apical extracellular matrix and epidermis

    Dina Aggad, Nicolas Brouilly ... Nathalie Pujol
    Combining live imaging and advanced electron microscopy gives insights into the structural integrity of the nematode epidermis and its intimate connection with the extracellular matrix.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects

    Antoine Vigouroux, Baptiste Cordier ... Sven van Teeffelen
    Class-A penicillin-binding proteins are dispensable for rod-like cell-shape but essential for mechanical integrity by sensing and repairing cell-wall defects locally, as investigated in the model system Escherichia coli.
    1. Neuroscience
    2. Physics of Living Systems

    Rapid mechanical stimulation of inner-ear hair cells by photonic pressure

    Sanjeewa Abeytunge, Francesco Gianoli ... Andrei S Kozlov
    A new method is described to apply rapid and uniform mechanical forces to vestibular and cochlear hair cells.
    1. Computational and Systems Biology

    Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

    Louis Gall, Carrie Duckworth ... Carmen Pin
    Novel modelling strategies can integrate the dynamics of processes regulating the intestinal epithelium at multiple scales in homeostasis and following perturbations to provide unprecedented insights into the biology of the epithelium and support the development of safer novel drug candidates.

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