Melanie Holmgren, Michael E Ravicz ... Lavinia Sheets
Mechanically induced injury of zebrafish lateral-line organs shares key features of damage observed in noise-exposed mammalian ears, such as inflammation and synapse loss, yet, unlike mammals, rapidly repairs following damage.
Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
Alexandra M Fister, Adam Horn ... Anna Huttenlocher
Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.
Combining live imaging and advanced electron microscopy gives insights into the structural integrity of the nematode epidermis and its intimate connection with the extracellular matrix.
Antoine Vigouroux, Baptiste Cordier ... Sven van Teeffelen
Class-A penicillin-binding proteins are dispensable for rod-like cell-shape but essential for mechanical integrity by sensing and repairing cell-wall defects locally, as investigated in the model system Escherichia coli.
Novel modelling strategies can integrate the dynamics of processes regulating the intestinal epithelium at multiple scales in homeostasis and following perturbations to provide unprecedented insights into the biology of the epithelium and support the development of safer novel drug candidates.