4,701 results found
    1. Developmental Biology

    YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

    Chuwen Lin et al.
    The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
    1. Immunology and Inflammation

    The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

    Zhengpeng Wan et al.
    The B cell receptors of naïve B cells need higher levels of mechanical force to be fully activated than those of memory B cells.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian et al.
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Physics of Living Systems
    2. Developmental Biology

    Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

    Tae-Jin Kim et al.
    Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.
    1. Cell Biology
    2. Neuroscience

    Piezo1 links mechanical forces to red blood cell volume

    Stuart M Cahalan et al.
    In red blood cells, the Piezo1 protein is responsible for sensing mechanical forces and volume regulation.
    1. Physics of Living Systems

    Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

    Fabian Baumann et al.
    Atomic force microscopy based single-molecule force spectroscopy of smooth muscle myosin light chain kinase strongly indicates the existence of a mechanically triggerable activation pathway analogous to its well-established biochemical regulation pathway via calcium-loaded calmodulin.
    1. Computational and Systems Biology
    2. Developmental Biology

    Why plants make puzzle cells, and how their shape emerges

    Aleksandra Sapala et al.
    Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

    Michael S Woody et al.
    Cardiac myosin converts energy from ATP into mechanical work by transitioning from a short-lived force-bearing state, to a post working stroke state before the release of inorganic phosphate.
    1. Developmental Biology
    2. Physics of Living Systems

    Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

    Amelia J Thompson et al.
    During embryonic development, tissue stiffness, which provides an important signal to motile cells, changes locally within tens of minutes in a well-controlled manner.
    1. Cell Biology

    Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

    Mei Rosa Ng et al.
    The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.

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