2,823 results found
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff et al.
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Computational and Systems Biology
    2. Developmental Biology

    Why plants make puzzle cells, and how their shape emerges

    Aleksandra Sapala et al.
    Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta et al.
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Structural Biology and Molecular Biophysics

    Piezo’s membrane footprint and its contribution to mechanosensitivity

    Christoph A Haselwandter, Roderick MacKinnon
    Membrane mechanics predict that the ion channel Piezo recruits the surrounding membrane to amplify its sensitivity to changes in membrane tension, with greatest sensitivity in the low-tension regime.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    Science Forum: A Global lmmunological Observatory to meet a time of pandemics

    Michael J Mina et al.
    The COVID-19 pandemic has clearly demonstrated the need for a global system to monitor the dynamics of susceptibility and immunity, as well as infection, during epidemics and pandemics.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian et al.
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Cancer Biology

    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

    John Kerwin et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.

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