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    1. Cell Biology
    2. Physics of Living Systems

    Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

    Matthew Akamatsu, Ritvik Vasan ... David G Drubin
    An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.
    1. Neuroscience

    Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

    Josette J Wlaschin, Jacob M Gluski ... Claire E Le Pichon
    The DLK response pathway in neurons initiates the cascade of events leading to neuropathic pain after injury.
    1. Evolutionary Biology

    Wings and halteres act as coupled dual oscillators in flies

    Tanvi Deora, Siddharth S Sane, Sanjay P Sane
    Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
    1. Neuroscience

    Stretching the skin immediately enhances perceived stiffness and gradually enhances the predictive control of grip force

    Mor Farajian, Raz Leib ... Ilana Nisky
    Elucidating the contribution of augmented artificial skin-stretch stimulation to the fingertips to the immediate illusion of a higher stiffness and to an increased predictive grip force control.
    1. Medicine

    Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading

    Dezhi Zhao, Manuel A Riquelme ... Jean X Jiang
    Connexin 43 hemichannel activation associated with prostaglandin release in osteocytes plays an important role in anabolic function of mechanical loading on bone tissue and hemichannels could be a potential new therapeutic target for treating bone loss and osteoporosis.
    1. Cell Biology

    A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle

    Kent W Jorgenson, Jamie E Hibbert ... Troy A Hornberger
    A novel imaging method for measuring myofibril size/number reveals that the radial growth of muscle fibers that occurs in response to increased mechanical loading is largely mediated by myofibrillogenesis.
    1. Cell Biology
    2. Physics of Living Systems

    Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

    Artur Ruppel, Dennis Wörthmüller ... Martial Balland
    Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke, Michael Powell ... Susan Athey
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
    1. Physics of Living Systems

    Flower-like patterns in multi-species bacterial colonies

    Liyang Xiong, Yuansheng Cao ... Lev Tsimring
    Mechanical interactions between bacterial species with different motility characteristics play an important role in spatial-temporal dynamics of multi-species bacterial colonies and can lead to formation of complex patterns.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

    Xiaofei Bai, Jeff Bouffard ... Andy Golden
    Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.