16,289 results found
    1. Plant Biology

    Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

    Firas Bou Daher, Yuanjie Chen ... Siobhan A Braybrook
    Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
    1. Developmental Biology
    2. Physics of Living Systems

    Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye

    Kevin D Gallagher, Madhav Mani, Richard W Carthew
    Formation of a triangular lattice of photoreceptor clusters in the compound eye is driven by highly regulated cell flows in the eye epithelium, through a mechanochemical mechanism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of chiral proofreading during translation of the genetic code

    Sadeem Ahmad, Satya Brata Routh ... Rajan Sankaranarayanan
    Structural biology has elucidated the mechanism of a configuration-specific enzyme that decouples D-amino acids from the translational machinery and, therefore, is involved in the enforcement of homochirality during protein synthesis.
    1. Cell Biology
    2. Physics of Living Systems

    Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

    Pooja Suresh, Vahe Galstyan ... Sophie Dumont
    Coarse-grained modeling of mammalian kinetochore-fiber shapes generated under microneedle manipulation reveals the need for lateral anchorage 1-3 μm from the kinetochore to robustly preserve their orientation in the spindle center, promoting mechanical integrity in the dynamic spindle.
    1. Cell Biology
    2. Neuroscience

    Intrinsic excitability mechanisms of neuronal ensemble formation

    Tzitzitlini Alejandre-García, Samuel Kim ... Rafael Yuste
    Optogenetic and electrical stimulation of primary visual cortex neurons reveals synaptic and cell-intrinsic mechanisms that underlie neuronal ensemble formation.
    1. Structural Biology and Molecular Biophysics

    Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    The use of a conformation-selective inhibitory nanobody provides critical information on MelB at a low-sugar affinity inward-facing Na+-bound state for establishing the mobile barrier and substrate-releasing mechanisms.
    1. Neuroscience

    Multiple mechanisms link prestimulus neural oscillations to sensory responses

    Luca Iemi, Niko A Busch ... Vadim V Nikulin
    Neural oscillations prior to a stimulus modulate the strength of early and late responses in opposite directions via distinct mechanisms.
    1. Developmental Biology
    2. Physics of Living Systems

    Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing

    Romina Piscitello-Gómez, Franz S Gruber ... Suzanne Eaton
    Quantitative analysis of cell dynamics over a range of timescales reveals that core PCP is not required to organize large-scale tissue flows but does affect short timescale mechanics.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

    Amy R Strom, Ronald J Biggs ... Andrew D Stephens
    Micromanipulation experiments demonstrate that HP1α strengthens interphase and mitotic chromosome mechanics and maintains nuclear shape by chromatin crosslinking, separate from histone methylation.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

    Nicholas E Bush, Christopher L Schroeder ... Mitra JZ Hartmann
    Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.

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