42 results found
    1. Cell Biology
    2. Physics of Living Systems

    Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

    Jacopo Di Russo et al.
    The use of nanopatterned hydrogels and specific integrin α5β1 peptidomimetic revealed that keratinocytes require an optimum inter-ligand spacing to best propagate intercellular forces and efficiently coordinate cell sheet migration.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix et al.
    A quantitative understanding of molecular tension sensor function enables the production of unique sensors with desired mechanical properties as well as the ability to distinguish between protein force and protein deformation in mechanosensitive processes.
    1. Developmental Biology

    An essential role for maternal control of Nodal signaling

    Pooja Kumari et al.
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    1. Plant Biology

    Dynamic F-actin movement is essential for fertilization in Arabidopsis thaliana

    Tomokazu Kawashima et al.
    The movement of F-actin filaments, which is regulated by actin-myosin interactions together with a female gamete-specific Rho-GTPase, enables migration of the Arabidopsis sperm cell nucleus towards the female nucleus; which might account for the loss of centrosomes in flowering plants.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai et al.
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei et al.
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

    Zhongwen Chen et al.
    EphA2 receptor clustering enhances signaling transductions by increasing receptor phosphorylation and binding dwell time of downstream molecules in living cells.
    1. Cell Biology
    2. Physics of Living Systems

    Myosin II isoforms play distinct roles in adherens junction biogenesis

    Mélina L Heuzé et al.
    Myosin isoforms exhibit different functions in the formation of adherens junctions and the transmission of mechanical forces.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook et al.
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Physics of Living Systems
    2. Stem Cells and Regenerative Medicine

    Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

    Arne D Hofemeier et al.
    Combining global and local force measurements of reconstituted muscle tissue using a new chamber system that is compatible with high-resolution microscopy shows mechanical homeostasis already within a week.

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