85 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

    Yao Rong et al.
    Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane Proteins: Pain or gain?

    Valeria Kalienkova
    The 3D structures of a membrane protein called TMEM120A suggest that it may act as an enzyme in fat metabolism rather than as an ion channel that senses mechanical pain.
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    1. Neuroscience
    2. Physics of Living Systems

    Decoding locomotion from population neural activity in moving C. elegans

    Kelsey M Hallinen et al.
    Neurons in the brain exhibit activity with various relations to locomotion and these signals are best decoded by combining activities from many neurons.
    1. Structural Biology and Molecular Biophysics

    Analysis of the mechanosensor channel functionality of TACAN

    Yiming Niu et al.
    Electrophysiological and structural data do not support a mechanosensitive channel function for TACAN.
    1. Developmental Biology
    2. Neuroscience

    Characterization of cephalic and non-cephalic sensory cell types provides insight into joint photo- and mechanoreceptor evolution

    Roger Revilla-i-Domingo et al.
    Molecular, cellular and behavioral genetic approaches in Platynereis dumerilii indicate that r-Opsins can act as ancient, light-dependent modulators of mechanosensation, and suggest that light-independent mechanosensory roles of r-Opsins evolved secondarily.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    T cell stiffness is enhanced upon formation of immunological synapse

    Philipp Jung et al.
    Upon activation of T cell receptors at the contact site, T cells were substantially stiffened at the cell body as well as at the lamellipodia, which is mediated by Ca2+.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Neuroscience

    Multiple neuronal networks coordinate Hydra mechanosensory behavior

    Krishna N Badhiwala et al.
    Despite lacking traditional ganglia or centralization, the Hydra nervous system computes sensorimotor responses via localized neuron ensembles.
    1. Microbiology and Infectious Disease

    A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

    Noopur Dave et al.
    Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

    Saurabh Kulkarni et al.
    Embryonic and mechanical manipulations of Xenopus multiciliated epithelium reveals that cell non-autonomous tensile forces generated by embryonic elongation calibrate cilia number in multiciliated cells via a mechanosensitive ion channel, Piezo1.

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