144 results found
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

    Yang Wang et al.
    A pushing force on the ankyrin repeat region of NompC leads to the gating of the mechanosensitive ion channel, which may enable cells to feel compression and shrinkage.
    1. Microbiology and Infectious Disease

    A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

    Noopur Dave et al.
    Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.
    1. Structural Biology and Molecular Biophysics

    Structure-based membrane dome mechanism for Piezo mechanosensitivity

    Yusong R Guo, Roderick MacKinnon
    Mechanosensitive Piezo channel induces local membrane curvature to mediate mechanical gating.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

    Bharat Reddy et al.
    The structure of the mechanosensitive channel MscS embedded in a lipid bilayer redefines the nature, location and importance of lipid–protein interactions in the gating of mechanosensitive channels.
    1. Cell Biology

    The mechanosensitive Piezo1 channel is required for bone formation

    Weijia Sun et al.
    Piezo1 functions as a key mechanotransducer for conferring mechanosensitivity to osteoblasts and determining mechanical-load-dependent bone formation, and represents a novel therapeutic target for treating osteoporosis or unloading-induced severe bone loss.
    1. Neuroscience

    The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

    Stephen G Brohawn et al.
    The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

    Josefina Inés del Mármol et al.
    Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.
    1. Structural Biology and Molecular Biophysics

    Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel

    Yong Wang et al.
    Observation by single molecule FRET of MscL, a prokaryotic mechanosensitive channel, reveals that MscL opens via the helix-tilt model and its pore reaches 2.8 nm in diameter.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

    Xiaofei Bai et al.
    Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
    1. Structural Biology and Molecular Biophysics

    Analysis of the mechanosensor channel functionality of TACAN

    Yiming Niu et al.
    Electrophysiological and structural data do not support a mechanosensitive channel function for TACAN.

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