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    1. Neuroscience

    Dopamine signaling tunes spatial pattern selectivity in C. elegans

    Bicheng Han et al.
    Natural variations in touch-dependent dopamine signaling tune the perception of spatial patterns in C. elegans.
    1. Neuroscience

    Acetylated tubulin is essential for touch sensation in mice

    Shane J Morley et al.
    Increased stiffness of sensory neurons in the absence of microtubule acetylation renders mice profoundly insensitive to touch and pain.
    1. Neuroscience

    Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury

    Margarita Calvo et al.
    Type 1 potassium channels alter their composition and localisation to suppress hyper-excitability and neuropathic pain of injured sensory neurons.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys et al.
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Physics of Living Systems
    2. Neuroscience

    Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

    Amanda H Lewis, Jörg Grandl
    Tension is the activating stimulus of Piezo1 mechanosensitive ion channels and resting membrane tension modulates overall channel sensitivity to mechanical stimulation.
    1. Neuroscience

    The signaling lipid sphingosine 1-phosphate regulates mechanical pain

    Rose Z Hill et al.
    Constitutive sphingosine 1-phosphate signaling via the G-protein coupled receptor S1PR3 in mechanonociceptive somatosensory neurons is required for normal behavioral responses to noxious mechanical stimuli.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

    M Rocio Servin-Vences et al.
    The application of different types of mechanical stimuli to chondrocytes, either by stretching the membrane or deflecting cell-substrate contacts, reveals that there are distinct but overlapping mechanoelectrical transduction pathways in these cells.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

    Su-Jin Heo et al.
    Nuclear reorganization and stiffening accompanies mesenchymal stem cell differentiation, resulting in increased sensitivity to mechanical perturbation.
    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

    Hua Deng et al.
    A contractile structural protein of the membrane-associated cytoskeleton is a Hippo signaling component that works through the regulation of non-muscle myosin activity in Drosophila.