4,994 results found
    1. Neuroscience

    Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

    Tim James Viney et al.
    GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan et al.
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

    Shuguang Yu, Jie He
    The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
    1. Neuroscience

    Synchronized excitability in a network enables generation of internal neuronal sequences

    Yingxue Wang et al.
    Hippocampal sharp-wave sequences, which are considered the key phenomenon underlying consolidation of episodic memory, are preserved even after an animal’s memory is impaired.
    1. Medicine

    Lipocalin-2 is an anorexigenic signal in primates

    Peristera-Ioanna Petropoulou et al.
    Lipocalin-2 is a strong predictor of hunger scores, reflects an anti-obesity response that is deregulated in severely obese subjects, and exerts an anorexigenic function with a conserved interspecies mechanism.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Microbiology and Infectious Disease

    Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

    Megan Okada et al.
    Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

    Wenn-Chyau Lee et al.
    Plasmodium parasites use host-derived factors to form more rosettes and hamper phagocytosis, representing a new escape mechanism for the malaria parasites.
    1. Neuroscience

    Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

    Przemyslaw Jarzebowski et al.
    Elevated cholinergic activity disrupts offline hippocampal state and impairs memory formation highlighting the need for a precise timing of cholinergic activity in learning and memory.
    1. Cell Biology

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

    Vladimir Purvanov et al.
    siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.

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