1,366 results found
    1. Microbiology and Infectious Disease

    Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

    Jennifer A Taylor, Benjamin P Bratton ... Nina R Salama
    The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
    1. Cell Biology

    Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

    Aidan M Fenix, Abigail C Neininger ... Dylan T Burnette
    Sarcomeres in heart muscle cells come from stress fiber-like structures that are mechanistically distinct from stress fibers in non-muscle cells.
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu, Anastasia Chrysidou ... Esther Kuehn
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Ecology
    2. Microbiology and Infectious Disease

    Universal gut microbial relationships in the gut microbiome of wild baboons

    Kimberly E Roche, Johannes R Bjork ... Elizabeth A Archie
    In baboon gut microbiota, most pairwise correlations in bacterial abundances are weak and negative, and bacterial correlation patterns are largely shared across hosts, rather than personalized to each hosts.
    1. Neuroscience

    Analysis of ultrasonic vocalizations from mice using computer vision and machine learning

    Antonio HO Fonseca, Gustavo M Santana ... Marcelo O Dietrich
    An open-source tool based on computational vision and machine learning shows high accuracy and sensitivity in the analysis of ultrasonic vocalizations.
    1. Microbiology and Infectious Disease

    Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

    Louis Shekhtman, Miquel Navasa ... Harel Dahari
    Very frequent viral kinetics in liver transplant patients reveals that the liver is not only the source of hepatitis C virus (HCV) production, but also plays a major role in extracellular HCV clearance.
    1. Computational and Systems Biology
    2. Neuroscience

    High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

    George A Spirou, Matthew Kersting ... Paul B Manis
    Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
    1. Developmental Biology

    SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity

    Sonia Alonso-Martin, Frédéric Auradé ... Frédéric Relaix
    A set of ex vivo and in vivo experiments, including genetic ablation and regeneration studies, identify a key regulatory function of SOXF factors in muscle stem cells in mice.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips, Cerys S Manning ... Nancy Papalopulu
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Structural Biology and Molecular Biophysics

    Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

    SeCheol Oh, Fabrizio Marinelli ... Richard K Hite
    The energetic costs of ion dehydration in the pore of human TMEM175 determine its ion selectivity.

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