4,348 results found
    1. Epidemiology and Global Health

    Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

    Neil Martin Davies, W David Hill ... George Davey Smith
    Many of the effects of intelligence on health and social outcomes later in life are mediated via education.
    1. Genetics and Genomics

    Can education be personalised using pupils’ genetic data?

    Tim T Morris, Neil M Davies, George Davey Smith
    Current polygenic scores for education do not provide accurate predictions of educational achievement above other data or at the individual level.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease

    Jiahui Si, Jiachen Li ... Jun Lv
    Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
    1. Neuroscience

    Neural mediation of greed personality trait on economic risk-taking

    Weiwei Li, Haixia Wang ... Jian Li
    Greed personality trait is associated with behavioral loss aversion via the mediation of the neural loss aversion signal in the medial orbitofrontal cortex.
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo, Sabrina Totaro ... Corrado Corradi-Dell'Acqua
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
    1. Neuroscience

    Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease

    John P Grogan, Demitra Tsivos ... Elizabeth J Coulthard
    Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

    Jiahui Si, Songchun Yang ... China Kadoorie Biobank Collaborative Group
    Epigenetic regulations in the smoking- and blood pressure-related pathways to the future risk of coronary heart disease may reveal novel pathways or therapeutic targets.
  1. Being Neurodivergent in Academia: Navigating neurodiversity in higher education in India

    Deepali Taneja, Poornima Viswanathan, Sahana V Rajan
    True inclusion starts in academia when we move from a deficit-based perspective to one that recognises and nurtures the unique strengths and talents of neurodivergent individuals.
    1. Medicine

    Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

    Guorong Li, Chanyoung Lee ... W Daniel Stamer
    An FDA-approved, rho-associated kinase inhibitor reverses fibrosis in the conventional outflow pathway of a mouse model of glaucoma and reverses ocular hypertension in patients with steroid glaucoma.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais, Marie Marotel ... Thierry Walzer
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.

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