45 results found
    1. Cell Biology
    2. Developmental Biology

    miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

    Elik Chapnik et al.
    miR-142 is instrumental for actin homeostasis, and its loss disrupts the cytoskeleton organization and thrombopoiesis of megakaryocytes.
    1. Cell Biology

    Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

    Pierre Cunin et al.
    In a novel cell-in-cell interaction termed emperipolesis, neutrophils routinely transit through the cytoplasm of bone marrow megakaryocytes to pass surface membrane to newly-generated hybrid platelets.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Biochemistry and Chemical Biology

    Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

    Li Zhang et al.
    Inhibiting PRMT1 enzymatic activity promotes megakaryocyte terminal differentiation via RBM15-mediated RNA metabolism, which is dysregulated in hematological malignancies.
    1. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

    Bo O Zhou et al.
    Normal hematopoietic stem and progenitor cells slow the regeneration of their niche after injury to minimize leakage from the niche vasculature.
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen et al.
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Immunology and Inflammation

    B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

    Eric E Irons et al.
    B cells regulate production of neutrophils by a novel mechanism by releasing ST6Gal-1, an active sialyltransferase, that suppresses granulopoiesis.
    1. Developmental Biology
    2. Neuroscience

    Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

    Youngshik Choe et al.
    During development the Sonic Hedgehog protein is produced by epithelial structures and acts at a distance in the brain and perhaps in other organs.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte et al.
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.

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