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    1. Cell Biology

    Evidence that a positive feedback loop drives centrosome maturation in fly embryos

    Ines Alvarez-Rodrigo et al.
    Polo kinase recruitment by the protein Spd-2 to the pericentriolar scaffold is a key element of the positive feedback loop which drives the expansion of the mitotic centrosomes in flies.
    1. Evolutionary Biology

    Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex

    Marco Colnaghi et al.
    Lateral gene transfer is unable to resist mutation accumulation in large genomes, leading to selective pressure for the origin of meiotic sex in the first eukaryotes.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet et al.
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.
    1. Immunology and Inflammation
    2. Neuroscience

    Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization

    Wenxin Ma et al.
    TGFβ signaling to retinal microglia is central to the regulation of neuroinflammatory responses relevant to age-related macular degeneration (AMD), a leading cause of blindness in the developed world.
    1. Cell Biology
    2. Computational and Systems Biology

    The nucleus serves as the pacemaker for the cell cycle

    Oshri Afanzar et al.
    Just as the sinoatrial node acts as pacemaker for the heart, the nucleus acts as pacemaker for the Xenopus embryonic cell cycle.
    1. Cell Biology

    Male meiotic spindle features that efficiently segregate paired and lagging chromosomes

    Gunar Fabig et al.
    Chromosome segregation in male spermatocytes exhibits anaphase A without shortening of autosome-associated microtubules and partitioning of an unpaired X chromosome that is initiated by an imbalance of attached kinetochore microtubules.
    1. Cell Biology

    Mammalian cell growth dynamics in mitosis

    Teemu P Miettinen et al.
    High-resolution single-cell mass accumulation and protein synthesis rate measurements are used to quantify the extent, dynamics and consequences of animal cell growth in mitosis and cytokinesis.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan et al.
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    1. Cancer Biology
    2. Developmental Biology

    Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

    Karine Narbonne-Reveau et al.
    Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet et al.
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.