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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Siglec receptors impact mammalian lifespan by modulating oxidative stress

    Flavio Schwarz et al.
    By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

    Patrick Laurette et al.
    The PBAF chromatin-remodelling complex is essential for the proliferation of melanocytes and melanoma cells and is recruited to critical regulatory elements by physical and functional interactions with MITF, a transcription factor and master regulator of melanoma.
    1. Neuroscience

    An opioid-like system regulating feeding behavior in C. elegans

    Mi Cheong Cheong et al.
    The discovery that opioid neuropeptide neuronal signaling controls feeding behavior in a genetically tractable invertebrate model may help unravel the mechanisms of appetite control in humans.
    1. Neuroscience

    Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

    Thomas O Auer et al.
    Disrupting synapse formation between the retina and the brain in zebrafish larvae-by eliminating the molecular motor Kif5A-triggers a compensatory increase in the branching of retinal axons aimed at restoring synapse number.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Cancer-associated TERT promoter mutations abrogate telomerase silencing

    Kunitoshi Chiba et al.
    TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

    Andreu Viader et al.
    Cell-specific pathways regulate lipid transmitters and neuroinflammation in the brain.
    1. Developmental Biology
    2. Evolutionary Biology

    Long-distance communication by specialized cellular projections during pigment pattern development and evolution

    Dae Seok Eom et al.
    Cells of the xanthophore lineage form projections that allow them to communicate with other pigment cells during adult pigment pattern formation in zebrafish, but not in the closely-related pearl danio.
    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.
    1. Genetics and Genomics
    2. Neuroscience

    Epigenomic landscapes of retinal rods and cones

    Alisa Mo et al.
    Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.