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    1. Cell Biology
    2. Neuroscience

    Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

    Santiago Vernia et al.
    Metabolic stress-induced activation of the JNK3 protein regulates excitatory transmission onto AgRP neurons to regulate food consumption.
    1. Cell Biology
    2. Neuroscience

    Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

    Damien Lanfray et al.
    The Acyl-CoA binding domain-containing 7 (Acbd7) gene is expressed in the hypothalamus, encodes a peptide that suppresses appetite, increases metabolic rate and interacts with the leptin-melanocortin system.
    1. Cell Biology

    Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale et al.
    Two receptors have been identified that can be targeted in melanocytes with selective small molecule agonists to modulate human skin color.
    1. Cancer Biology

    Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth

    Romi Gupta et al.
    The protein IFI6 regulates DNA replication via the transcription factor E2F2, which is necessary for transformation and growth of melanomas induced by the NRASQ61K mutant oncogene product.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

    Chintan K Kikani et al.
    PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
    1. Computational and Systems Biology

    A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference

    Dina Cramer et al.
    The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.
    1. Cell Biology
    2. Developmental Biology

    BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development

    Jaeyoung Shin et al.
    Genetic and biochemical approaches identify a new component of the cellular signaling machinery driving migration of limb muscle precursor cells during mouse embryogenesis and reveal the underlying molecular mechanism.
    1. Cancer Biology
    2. Developmental Biology

    Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

    Shaina N Porter et al.
    Age-specific transcriptional responses to Flt3-ITD and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult, but not fetal/neonatal, stages of development.
    1. Cancer Biology

    Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

    Stephen K Horrigan et al.
    Editors' Summary: The results in this Replication Study could not be interpreted.
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman et al.
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.