307 results found
    1. Immunology and Inflammation

    Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

    Anders Laustsen et al.
    Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz et al.
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum

    Olivier Cochet-Escartin et al.
    Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
    1. Developmental Biology

    Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

    Hyae Yon Kweon et al.
    Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

    Sierra M Barone et al.
    Rare, virus-specific immune cells in human blood are automatically identified by machine learning algorithm T-REX and characterized for signature features needed for tracking and isolation.
    1. Cell Biology

    VASP-mediated actin dynamics activate and recruit a filopodia myosin

    Ashley L Arthur et al.
    Filopodia formation requires recruitment and activation of myosin through generation of parallel, bundled actin filaments by VASP polymerase, revealing coupling between motor activation and organization of a local actin network.
    1. Cancer Biology
    2. Medicine

    Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

    Xinbo Qiao et al.
    CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
    1. Genetics and Genomics

    HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

    Jessica SY Ho et al.
    HNRNPM regulates exon inclusion and circularization events on transcripts of key homeostatic genes promoting cancer growth.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic consequences of hybridization

    Benjamin M Moran et al.
    A synthesis of recent hybridization literature reveals emerging patterns in the evolution of genomes after hybridization, processes proposed to explain those patterns, and important open questions to direct future hybrid genomics research.
    1. Cell Biology
    2. Genetics and Genomics

    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

    Jiajia Ma et al.
    The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.

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