Browse the search results

Page 2 of 26
    1. Computational and Systems Biology

    Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received

    Ran Liu et al.
    Spectral clustering applied to risk trajectories of sepsis patients discovered four distinct clusters stratified by risk of septic shock, mortality, and treatments received prior to an abrupt physiological transition.
    1. Computational and Systems Biology

    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

    Anusorn Mudla et al.
    Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
    1. Ecology
    2. Epidemiology and Global Health

    Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C

    Marta S Shocket et al.
    Mechanistic, trait-based models for transmission of West Nile virus and observed incidence of human West Nile disease cases in the US both show optimal transmission at 24-25°C.
    1. Cancer Biology
    2. Immunology and Inflammation

    Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Biancamaria Ricci et al.
    Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING

    Sytse J Piersma et al.
    Cytomegaloviruses are recognized by distinct sensors depending on the infected cell type and together these sensors are essential for viral control and downstream immune responses.
    1. Microbiology and Infectious Disease

    Expression of different L1 isoforms of Mastomys natalensis papillomavirus as mechanism to circumvent adaptive immunity

    Yingying Fu et al.
    Cutaneous papillomaviruses potentially escape humoral immune response by synthesizing an alternative major capsid protein isoform during the initial course of infection that is unable to induce neutralizing antibodies.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen et al.
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Immunology and Inflammation

    Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

    Eui Ho Kim et al.
    Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.
    1. Developmental Biology
    2. Immunology and Inflammation

    Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice

    Ying Wang et al.
    A distinct resident macrophage subpopulation that localizes to the adipose stroma and fibrous capsule of the nulliparous mammary gland and to extracellular matrix-enriched stroma surrounding mammary tumors is identified.