544 results found
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

    Liang Ge et al.
    A cell-free biochemical assay for protein lipidation identifies the ER–Golgi intermediate compartment as a key early station in the formation of an autophagosome.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis

    Shengben Li et al.
    Arabidopsis microRNAs and their effector protein ARGONAUTE1 associate with and act on polysomes on the rough endoplasmic reticulum.
    1. Developmental Biology

    Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis

    Daniel Sieiro et al.
    In chick skeletal muscle, an incoming signal leads to two interdependent outcomes: a cell fate change and an epithelial-mesenchymal transition.
    1. Cell Biology

    TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

    António JM Santos et al.
    Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology

    Independent evolution of functionally exchangeable mitochondrial outer membrane import complexes

    Daniela G Vitali et al.
    The convergent evolution of yeast Mim1/2 and trypanosomal pATOM36 enable the first demonstration of reciprocal functional rescue of two evolutionary unrelated mitochondrial biogenesis complexes belonging to two different eukaryotic supergroups.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The autophagic membrane tether ATG2A transfers lipids between membranes

    Shintaro Maeda et al.
    The autophagy protein ATG2A tethers membranes and transfers lipids between them, suggesting that autophagosome membranes grow upon the acquisition of lipids from the ER through the ATG2A bridge.
    1. Microbiology and Infectious Disease

    A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

    Anna Konovalova et al.
    Mutations that block assembly of the interlocked RcsF/β barrel protein complex prevent detection of lipopolysaccharide stress and activation of Rcs signal transduction pathway.

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