SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
Reetu Daswani, Carlotta Gilardi ... Gerhard Schratt
A new molecular mechanism involving microRNA, which controls synaptic transmission in a specialized type of inhibitory interneurons in the hippocampus and short-term memory in mice, was identified.
Human GDOWN1 is identified as an extremely tightly controlled nucleocytoplasmic shuttling protein, and its translocation into the nucleus plays a crucial role in modulating the global transcription and facilitating the cellular adaptation to certain stresses.
RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.