1,395 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

    Wenbo Liu, Xukun Lu ... Jianqiao Liu
    SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
    1. Developmental Biology

    Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration

    Ines Lahmann, Joscha Griger ... Carmen Birchmeier
    Met and Cxcr4 signaling protects muscle stem cells from the noxious environment during acute inflammation.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms

    Yoseop Yoon, Jeff Klomp ... Urs Schmidt-Ott
    Isoform-specific transcript localization underlies the evolutionary diversity of anterior axis determinants in embryos of dipteran insects.
    1. Cell Biology
    2. Developmental Biology

    Ciliary length regulation by intraflagellar transport in zebrafish

    Yi Sun, Zhe Chen ... Chengtian Zhao
    The speed of intraflagellar transport, influenced by particle size, shows a positive correlation with ciliary length in zebrafish.
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    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng, Luke Saville ... Athanasios Zovoilis
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Cell Biology
    2. Genetics and Genomics

    Differential requirements for mitochondrial electron transport chain components in the adult murine liver

    Nicholas P Lesner, Xun Wang ... Prashant Mishra
    Animal models reveal that mitochondrial complex I is dispensable for homeostatic functions of the mouse liver.
    1. Developmental Biology

    Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

    Chhavi Sood, Md Ausrafuggaman Nahid ... Sarah E Siegrist
    Notch signaling regulates the neuroblast intrinsic temporal program to determine when neuroblasts terminate their cell divisions during development.
    1. Neuroscience

    MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice

    Reetu Daswani, Carlotta Gilardi ... Gerhard Schratt
    A new molecular mechanism involving microRNA, which controls synaptic transmission in a specialized type of inhibitory interneurons in the hippocampus and short-term memory in mice, was identified.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Overcoming the cytoplasmic retention of GDOWN1 modulates global transcription and facilitates stress adaptation

    Zhanwu Zhu, Jingjing Liu ... Bo Cheng
    Human GDOWN1 is identified as an extremely tightly controlled nucleocytoplasmic shuttling protein, and its translocation into the nucleus plays a crucial role in modulating the global transcription and facilitating the cellular adaptation to certain stresses.
    1. Developmental Biology
    2. Neuroscience

    Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

    Kawssar Harb, Melanie Richter ... Kent Duncan
    RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

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