As the function of membrane proteins is often influenced by its membrane environment the presented combinatorial approach is of great value for the investigation of membrane protein complexes in natural or even manipulated lipid bilayers.
An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
Unprecedented resolution of the molecular mechanisms of plant membrane protein anchoring involving phospholipids and sterols reveals the control of spatio-temporal segregation into plasma membrane nanodomains.