207 results found
    1. Structural Biology and Molecular Biophysics

    A label-free approach to detect ligand binding to cell surface proteins in real time

    Verena Burtscher et al.
    Binding of a charged small molecule to a membrane protein changes the amplitude of the apparent membrane capacitance by changing the charge density at the surfaces of the membrane.
    1. Structural Biology and Molecular Biophysics

    Electrophysiology: Leading the charge

    Andrew JR Plested
    A simple label-free method uses the electrical properties of cells to detect how ligands bind to membrane proteins.
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    1. Neuroscience

    Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

    Sébastien Houy et al.
    Doc2B functions in two distinct vesicle priming steps; membrane localization occludes upstream Ca2+-dependent priming, whereas Ca2+-binding and interaction with synaptotagmin-1, SNAREs, and Munc13-2 are involved in downstream priming, which makes vesicles readily releasable.
    1. Human Biology and Medicine
    2. Neuroscience

    Unique membrane properties and enhanced signal processing in human neocortical neurons

    Guy Eyal et al.
    Models and experiments reveal that human L2/3 pyramidal neurons have distinctively low specific membrane capacitance which might have a significant impact on signal processing in human neocortex.
    1. Neuroscience

    Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

    Yuji Okamoto et al.
    Capacitance measurements and pH imaging reveal distinct modes of uptake for endocytotic presynaptic membrane and proteins.
    1. Neuroscience

    Endocytosis: Recycling at synapses

    Owen P Gross, Henrique von Gersdorff
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    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Neuroscience

    Biophysics of object segmentation in a collision-detecting neuron

    Richard Burkett Dewell, Fabrizio Gabbiani
    Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity for escaping an impending threat.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.

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