361 results found
    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai et al.
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Cell Biology

    Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

    Milos Galic et al.
    Local inward plasma membrane deformations caused by actomyosin-dependent contraction trigger the dynamic recruitment of a curvature-sensitive actin-regulatory protein, which represents a receptor-independent auto-regulatory mechanism to control local actin polymerization dynamics at the plasma membrane.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara et al.
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain et al.
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Cell Biology

    Sphingomyelin metabolism controls the shape and function of the Golgi cisternae

    Felix Campelo et al.
    Association of curvature generating proteins to the Golgi membranes by sphingomyelin metabolism essentially controls the flatness of a Golgi cisterna that is necessary for efficient sorting and export.
    1. Structural Biology and Molecular Biophysics

    Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals

    Chimari Jiko et al.
    The transmembrane shape of the F1Fo ATP synthase monomer provides the molecular basis of high curvature at the ridges of mammalian mitochondrial cristae.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    TANGO1 membrane helices create a lipid diffusion barrier at curved membranes

    Ishier Raote et al.
    TANGO1 creates a barrier to control lipid and protein flux across fused secretory compartments.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote et al.
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Mechanics and dynamics of translocating MreB filaments on curved membranes

    Felix Wong et al.
    Principal curvature-dependent motion of bacterial actin MreB results in localization consistent with all known literature.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae

    Xinbo Wang et al.
    Immunoisolation combined with quantitative proteomics identifies 79 proteins enriched in the tubular endoplasmic reticulum and provides useful tool for analyzing this organelle's functions.

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