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512 results found
    1. Neuroscience

    Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits

    Viktor János Oláh et al.
    Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.
    1. Developmental Biology
    2. Neuroscience

    Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity

    Arani Roy et al.
    The development of neural responses proceeds through both the expansion and contraction of receptive field structure, and in addition depends upon changes in excitability of individual cells.
    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama et al.
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Neuroscience

    Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells

    Loïs S Miraucourt et al.
    Endocannabinoid activation of the CB1 receptor on retinal ganglion cells in the eye results in enhanced excitability and responsiveness to visual stimulation through a novel mechanism involving intracellular chloride regulation.
    1. Neuroscience

    Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

    Stéphanie Ratté et al.
    No single molecular change is uniquely necessary to cause neuropathic changes in primary afferent excitability; multiple different changes are sufficient.
    1. Neuroscience

    Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons

    Jegath C Athilingam et al.
    Serotonin changes passive membrane properties in prefrontal fast-spiking interneurons to affect not only neuronal excitability but also the temporal filtering of synaptic inputs with a preference for gamma-frequency summation.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Natural antisense transcripts regulate the neuronal stress response and excitability

    Xingguo Zheng et al.
    The mRNA that encodes a Drosophila sodium channel enables neurons to adapt to acute temperature changes, via a mechanism independent of its protein-coding role.
    1. Cell Biology
    2. Neuroscience

    Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

    Shirley Weiss et al.
    An unbiased genetic screen in Drosophila provides evidence for a direct link between glial Ca2+ 25 signaling and classical functions of glia in buffering external K+ as a mechanism to regulate neuronal excitability.
    1. Neuroscience

    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

    Niklas Byczkowicz et al.
    The cAMP-HCN pathway can control action potential conduction velocity providing neuromodulators with the ability to tune energy consumption and temporal delays across axons in the brain.
    1. Neuroscience

    Neural mechanisms of social learning in the female mouse

    Yuan Gao et al.
    After mating, female mice form a sensory memory of the stud male's pheromones that correlates with striking changes in responsiveness of the specific neural ensemble activated by her partner.

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