Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.

A canonical class III adenylate cyclase with a membrane anchor of six transmembrane spans is regulated by a receptor of similar design, the quorum-sensing receptor from Vibrio harveyi.

The lysosome membrane is a new functional location for the ESCRTs in yeast.

The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.

Synaptic vesicles undergo reversible tethering at the plasma membrane which is activity- and myosin V- dependent.

The proteins Bax and Bak, which increase the permeability of the mitochondrial membrane during apoptosis, are also crucial for generating a mitochondrial membrane pore that is specifically involved in necrosis.

Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.

Interleukin 6 (IL-6) can mediate pathogenesis of autoimmune diseases through its effects on mitochondrial function.

The core autophagy protein Atg8 plays non-autophagy roles through binding to an integral membrane protein Hfl1, which harbors an unusual Atg8-interacting motif.

A new synaptic scaffold important for neurotransmission and synaptic plasticity has been identified.