105 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions

    Elisa Merklinger et al.
    A hierarchical model explains the self-organization of membrane microdoomaims.
    1. Cell Biology
    2. Plant Biology

    Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

    Christoph A Bücherl et al.
    Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
    1. Cancer Biology
    2. Cell Biology

    Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

    Onur Cizmecioglu et al.
    A unique two-step mechanism of plasma membrane recruitment and activation governs G-protein-coupled receptor mediated PI3K signaling.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Nicholas C Vierra et al.
    A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
    1. Cell Biology

    Cell Biology: Hopping rim to rim through the Golgi

    Suzanne R Pfeffer
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

    Xuchen Hu et al.
    Macrophages release 30-nm vesicular particles enriched in accessible cholesterol during cellular locomotion, a discovery that is likely relevant to cholesterol disposal by these cells.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

    Justyna B Startek et al.
    The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.
    1. Cell Biology

    Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry

    Corey A H Allard et al.
    Dynamic signaling protein clusters sample and map the cell surface to ensure that cells divide at the proper size.
    1. Neuroscience

    A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

    Nan Jiang et al.
    Epidermal cells in vertebrates and invertebrates ensheath portions of somatosensory neurons via a conserved morphogenetic mechanism, and this ensheathment regulates morphogenesis and function of Drosophila nociceptive neurons.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang et al.
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.

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