110 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions

    Elisa Merklinger et al.
    A hierarchical model explains the self-organization of membrane microdoomaims.
    1. Cell Biology
    2. Plant Biology

    Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

    Christoph A Bücherl et al.
    Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
    1. Cancer Biology
    2. Cell Biology

    Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

    Onur Cizmecioglu et al.
    A unique two-step mechanism of plasma membrane recruitment and activation governs G-protein-coupled receptor mediated PI3K signaling.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Nicholas C Vierra et al.
    A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
    1. Cell Biology

    Cell Biology: Hopping rim to rim through the Golgi

    Suzanne R Pfeffer
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    1. Cell Biology

    β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

    Sophie Schobesberger et al.
    β3-AR signalling via cGMP in cardiomyocytes is regulated via phosphodiesterase 2 and 5 degradation, it is potentially cardioprotective, but dysregulated in heart failure through signal redistribution and higher phosphodiesterase activity.
    1. Cell Biology
    2. Developmental Biology

    Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

    Maia Kinnebrew et al.
    The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
    1. Biochemistry and Chemical Biology

    HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE

    Hongki Song et al.
    The tethering complex HOPS employs affinity for each of the 4 SNAREs to catalyze assembly of 3-SNARE intermediates, supporting an immediate burst of membrane fusion triggered by the 4th SNARE.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

    Xuchen Hu et al.
    Macrophages release 30-nm vesicular particles enriched in accessible cholesterol during cellular locomotion, a discovery that is likely relevant to cholesterol disposal by these cells.

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