3,214 results found
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov, Hiroyuki Watanabe ... Georgy Bakalkin
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Immunology and Inflammation

    IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

    Qian Wang, Christin M Lepus ... William H Robinson
    Osteoarthritis pathogenesis is driven by IgE-mediated mast cell activation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

    Clare M Smith, Richard E Baker ... Christopher M Sassetti
    A novel dual genome approach that combines genetically diverse mice and a library of bacterial mutants to define the genome-wide host pathogen interactions that drive distinct outcomes to tuberculosis.
    1. Developmental Biology
    2. Neuroscience

    Enteric glia as a source of neural progenitors in adult zebrafish

    Sarah McCallum, Yuuki Obata ... Tiffany A Heanue
    Characterization of a novel population of enteric nervous system glial cells in zebrafish reveals their proliferative and neurogenic properties under homeostatic conditions in adults, properties difficult to model in mammals.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

    Carolline Ascenção, Jennie R Sims ... Marcus B Smolka
    A Topbp1 mutant mouse reveals a non-canonical role for the ATR-TOPBP1 signaling axis in meiosis, separating ATR signaling and meiotic sex chromosome inactivation from sex body formation.
    1. Neuroscience

    Adaptation of spontaneous activity in the developing visual cortex

    Marina E Wosniack, Jan H Kirchner ... Julijana Gjorgjieva
    To generate stable and robust connectivity refinements, the amplitude of spontaneous activity events in the developing visual cortex adapts to the recent history of cortical activation.
    1. Developmental Biology
    2. Neuroscience

    The role of the NMD factor UPF3B in olfactory sensory neurons

    Kun Tan, Samantha H Jones ... Miles F Wilkinson
    The nonsense-mediated RNA decay (NMD) branch-specific factor UPF3B influences olfactory sensory neuron cell populations, the olfactory receptor repertoire, and antimicrobial gene expression.
    1. Cell Biology

    Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

    Kyounghee Min, Batuhan Yenilmez ... Michael P Czech
    Stellate cell lactate transporter MCT1 significantly contributes to liver fibrosis through increased collagen 1 protein expression in vitro and in vivo.
    1. Cancer Biology
    2. Computational and Systems Biology

    High-content microscopy reveals a morphological signature of bortezomib resistance

    Megan E Kelley, Adi Y Berman ... Gregory P Way
    Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.

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