3,214 results found
    1. Cell Biology
    2. Physics of Living Systems

    Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

    Ivan Castello-Serrano, Frederick A Heberle ... Ilya Levental
    Direct measurements of trafficking kinetics between organelles of the secretory pathway suggest that lipid-driven membrane domains laterally sort proteins during membrane traffic.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins

    Gabriella Angiulli, Harveer Singh Dhupar ... Thomas Walz
    Cryo-EM structures reveal how the peptidisc scaffold can adapt to different membrane proteins, establishing it as a universal membrane mimetic to stabilize membrane proteins in solution.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

    Enrico F Semeraro, Lisa Marx ... Georg Pabst
    The damage of the bacterial cell envelope is found to be only a secondary effect of the antimicrobial activity of lactoferricin derivatives.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule analysis of the entire perfringolysin O pore formation pathway

    Conall McGuinness, James C Walsh ... Till Böcking
    Arc-shaped PFO oligomers consisting of at least four subunits can insert into the membrane in a kinetically controlled process opening a transmembrane pore, whereby post-insertion growth may ultimately lead to formation of a complete ring.
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    Rupinder Singh Jandu, Mohammed Al-Seragi ... Franck Duong van Hoa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Cell Biology

    Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

    Qian Liu, Elizabeth J Osterlund ... David William Andrews
    The pro-apoptotic BH3-protein Bim contains two distinct binding sites for anti-apoptotic proteins that together confer resistance of Bim/Bcl-2 and Bim/Bcl-XL complexes to BH3-mimetic drugs under development for use in humans.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

    Scott D Hansen, Albert A Lee ... Jay T Groves
    Dimerization promotes nonlinear kinetics in PIP5K-dependent lipid phosphorylation reactions.
    1. Ecology
    2. Evolutionary Biology

    Mimicry can drive convergence in structural and light transmission features of transparent wings in Lepidoptera

    Charline Sophie Pinna, Maëlle Vilbert ... Marianne Elias
    Wing transparency in mimetic butterflies and moths is achieved by an unexpected diversity of structural features, and both structures and light transmission properties of wings are under selection for convergence.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes

    James M Pemberton, Dang Nguyen ... David W Andrews
    A second anti-apoptotic protein binding site in PUMA confers resistance to BH3 mimetic drugs and binds the protein to membranes.
    1. Structural Biology and Molecular Biophysics

    Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

    Seoyoon Kim, Daehyo Lee ... Duyoung Min
    An exceedingly low speed limit was estimated for a helical hairpin formation by analyzing hours-long, incessant structural transitions.

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