Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
Konstantinos Sousounis, Donald M Bryant ... Jessica L Whited
Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
Amrita Mukherjee, Paul S Brooks ... Paul T Conduit
The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.
SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
Ashutosh Pudasaini, Jae Sung Shim ... Brian D Zoltowski
In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.
Genomics-based evidence support population- and sex-specific selection of an epistatic interaction between genetic variants in ADCY9 and CETP, genes of pharmacogenetic importance in cardiovascular diseases.
NMNAT is genetically required for glioma development and promotes glioma growth by allowing a higher tolerance to DNA damage and inhibiting DNA damage-p53-caspase-3 apoptosis signaling pathway by enhancing NAD+-dependent posttranslational modifications (PTMs) poly(ADP-ribosyl)ation (PARylation) and deacetylation of p53.
Computational and theoretical biomechanical analysis reveals how actomyosin filaments and axial muscles conjugate their activity to realize a fourfold elongation during C. elegans embryogenesis, 4 hr just before hatching.
