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    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu, Christine Kyuyoung Lee ... Mark P Beenhakker
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

    Jennifer K Briggs, Anne Gresch ... Richard KP Benninger
    The functional network of β-cells in the pancreatic islet, which has been used to identify important subpopulations of β-cells implicated in diabetes progression, is indicative of intrinsic dynamics rather than structural communication, implying islet robustness.
    1. Neuroscience
    2. Physics of Living Systems

    Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

    Louis Kang, Michael R DeWeese
    An experimentally supported model of grid cells naturally enables them to participate in firing sequences that encode rapid trajectories in space.
    1. Neuroscience

    Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network

    Yaara Lefler, Oren Amsalem ... Yosef Yarom
    Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
    1. Cell Biology

    Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials

    Kamila Oglęcka, Padmini Rangamani ... Atul N Parikh
    Spontaneous osmoregulation in giant phospholipid vesicles, which is characterized by oscillations in vesicle size and membrane tension, couples to the compositional degrees of freedom at the membrane surface to produce oscillations in domain texture and induce isothermal phase change.
    1. Neuroscience

    Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude

    Elizabeth Nicholson, Dmitry A Kuzmin ... Dimitri Michael Kullmann
    Neurons can synchronize, supporting flexible communication among brain areas; closed-loop optogenetics allows the frequency and power of population oscillations to be dissociated, providing a tool to interrogate how networks couple.
    1. Computational and Systems Biology
    2. Medicine

    A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer ... Colleen E Clancy
    A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.
    1. Neuroscience

    Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits

    Viktor János Oláh, David Lukacsovich ... János Szabadics
    Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.
    1. Neuroscience

    Oscillations support short latency co-firing of neurons during human episodic memory formation

    Frédéric Roux, George Parish ... Simon Hanslmayr
    Synchronization of neural firing in the medial temporal lobe at fast, but not slow, theta and gamma oscillations correlates with shorter latencies of co-firing and successful memory formation.