3,204 results found
    1. Cell Biology
    2. Plant Biology

    Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

    Christoph A Bücherl et al.
    Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases

    Stephanie Beltz et al.
    A canonical class III adenylate cyclase with a membrane anchor of six transmembrane spans is regulated by a receptor of similar design, the quorum-sensing receptor from Vibrio harveyi.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

    Moutusi Manna et al.
    Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

    Akira Karasawa et al.
    Functional reconstitution of a mammalian P2X7 receptor uncovers an intrinsic and lipid-dependent dye-permeable membrane pore.
    1. Cell Biology
    2. Neuroscience

    Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth

    GaYoung Lee, Thomas L Schwarz
    Filamin, by recruiting a signaling complex to the postsynapse, orchestrates the correct formation and growth of postsynaptic membranes and localization of glutamate receptor subunits.
    1. Cell Biology

    Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia

    Alison Leaf, Mark Von Zastrow
    The mechanism of signaling receptor delivery to primary cilia involves a specific cellular role of a Rab protein that is critical for vertebrate development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

    Yu-Hsien Hwang Fu et al.
    Single molecule microscopy combined with biochemical analyses show that a two-step lipid-binding mechanism of the SRP receptor balances the trade-off between speed and specificity during co-translational protein targeting.
    1. Cell Biology

    Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

    Christopher A Natale et al.
    Two receptors have been identified that can be targeted in melanocytes with selective small molecule agonists to modulate human skin color.
    1. Cell Biology

    Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

    Fan Ye et al.
    Membrane receptor proteins move through primary cilia largely by passive diffusion rather than by active intraflagellar transport.
    1. Immunology and Inflammation

    Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

    Matthew B Stone et al.
    Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.

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