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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

    Benjamin König et al.
    VRAC activation, observed with a FRET sensor of intracellular LRRC8-domains movement during gating and by fluorometry, requires plasma membrane localization and diacylglycerol signaling, but is independent of intracellular ionic strength.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Nicholas C Vierra et al.
    A potassium channel, as a nonconducting function, organizes compartmentalized neuronal calcium signaling microdomains via structural and functional coupling of plasma membrane and endoplasmic reticulum calcium channels.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    High-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking

    Yerim Lee et al.
    The nanoscopic landscape of the membrane has a direct impact on the spatiotemporal, and likely also the signaling, dynamics of Ras proteins.
    1. Cell Biology

    Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling

    Shelly TH McClatchey et al.
    A Notch-mediated signaling pathway upregulates a Sec14-GOLD phosphopholipid binding protein that promotes a morphogenetic process important in tissue remodeling and renewal.
    1. Structural Biology and Molecular Biophysics

    Allosteric signalling in the outer membrane translocation domain of PapC usher

    Irene Farabella et al.
    Input from computational models has enabled the detection of allosteric communication that modulates the gating mechanism of a bacterial outer-membrane protein.
    1. Developmental Biology

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Cell Biology
    2. Neuroscience

    The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling

    Kathryn P Harris et al.
    Syntaxin 4 regulates retrograde signaling in the postsynaptic compartment at Drosophila synapses by controlling trafficking of Neuroligin and Synaptotagmin 4 cargo.
    1. Cell Biology
    2. Neuroscience

    The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

    Vladimir Zhemkov et al.
    Signaling function of sigma 1 receptor is related to its ability to organize cholesterol-enriched microdomains in the endoplasmic reticulum membrane.
    1. Neuroscience

    A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth in Caenorhabditis elegans

    Jiale Fan et al.
    The work uncovers a muscle-epidermis-glia signaling axis, modulated by protease mig-17 and the basement membrane, that regulates synaptic allometry during growth in Caenorhabditis elegans.
    1. Cell Biology
    2. Neuroscience

    Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

    Guiping Wang et al.
    Neurotrophin deprivation leads to rapid caspase-independent disassembly of the actin-spectrin-based membrane skeleton and spectrin-dependent retrograde signaling in axon degeneration.