3,893 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

    Diana C Rodriguez Camargo et al.
    The ability of lipid nanodiscs to trap different types of amyloid intermediates, as successfully demonstrated in this study for human-IAPP, could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
    1. Structural Biology and Molecular Biophysics

    Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake

    Inokentijs Josts et al.
    The crystal structure of a ternary complex of a TonB-dependent transporter containing a signalling domain, bound to siderophore as well as TonB, provides mechanistic insights into siderophore uptake and signalling.
    1. Plant Biology

    Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

    Julien Gronnier et al.
    Unprecedented resolution of the molecular mechanisms of plant membrane protein anchoring involving phospholipids and sterols reveals the control of spatio-temporal segregation into plasma membrane nanodomains.
    1. Cell Biology

    Magnetic resonance measurements of cellular and sub-cellular membrane structures in live and fixed neural tissue

    Nathan H Williamson et al.
    Low-field single-sided magnetic resonance diffusion methods detect and measure permeability of sub-micron compartments which likely include cell processes, organelles, and cellular vesicles within ex vivo mouse spinal cords.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

    Chanhyung Bae et al.
    The structure of a bivalent double-knot tarantula toxin bound to the outer pore of the capsaicin receptor reveals a novel mode of toxin-channel recognition that has important implications for thermosensation.
    1. Biochemistry and Chemical Biology

    Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

    Michael Zick et al.
    Lipids with a propensity to form nonbilayer structures must be present for the last step of membrane fusion to take place.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Structural Biology and Molecular Biophysics

    Structure and activation mechanism of the BBSome membrane protein trafficking complex

    Sandeep K Singh et al.
    Two cryo-EM structures of the mammalian BBSome show how the BBSome is recruited to membranes and activated by the GTPase ARL6 prior to binding transmembrane proteins.
    1. Cell Biology
    2. Developmental Biology

    Physical association between a novel plasma-membrane structure and centrosome orients cell division

    Takefumi Negishi et al.
    A newly discovered membrane structure associates with one of the centrioles and affects two important centrosomal events in epidermal cells – ciliary positioning and spindle orientation – through a physical interaction.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

    Shaogeng Tang et al.
    Snf7 crystal structures reveal the mechanisms of ESCRT-III activation and polymerization into membrane-remodeling filaments.

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