5,085 results found
    1. Biochemistry and Chemical Biology

    A pre-screening strategy to assess resected tumor margins by imaging cytoplasmic viscosity and hypoxia

    Hui Huang et al.
    A fluorescence-based pre-screening strategy allows high-throughput, convenient, and fast gross assessment of resected tumor margins by imaging cytoplasmic viscosity and hypoxia.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

    E Josue Ruiz et al.
    Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.
    1. Immunology and Inflammation

    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Kotaro Akaki et al.
    Regnase-1, an RNase suppressing proinflammatory mRNAs, interacts with 14-3-3, which diminishes cytokine mRNA recognition and the nuclear-cytoplasmic shuttling of Regnase-1 under inflammatory conditions.
    1. Cell Biology
    2. Developmental Biology

    SLC1A5 provides glutamine and asparagine necessary for bone development in mice

    Deepika Sharma et al.
    Osteoblasts utilize an elegant mechanism by which they obtain and subsequently synthesize the requisite amino acids to support osteoblast differentiation and bone formation.
    1. Computational and Systems Biology
    2. Neuroscience

    Evolving interpretable plasticity for spiking networks

    Jakob Jordan et al.
    Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.
    1. Cell Biology

    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

    Saeed Daneshmandi et al.
    6-Phosphogluconate dehydrogenase controls regulatory T cells metabolism with shifts to Th1, Th2, and Th17 phenotypes.
    1. Cell Biology

    Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation

    Hiroko Katsuno-Kambe et al.
    Integrin- and ERK signaling stimulates mammary epithelial cell proliferation when extracellular collagen condenses, causing asymmetric growth of multicellular aggregates that is necessary for elongation during branching morphogenesis.
    1. Neuroscience

    Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

    Taisuke Miyazaki et al.
    Excitatory and inhibitory postsynaptic receptors are maintained at corresponded postsynaptic sites with the different dependency of presynaptic neurons in the mature mammalian brain.
    1. Cancer Biology
    2. Cell Biology

    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

    Tomasz Radaszkiewicz et al.
    RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
    1. Cell Biology
    2. Developmental Biology

    Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

    Maureen C Lamb et al.
    Collectively migrating cells control their stiffness by Fascin-dependent control of Myosin activity, and this migratory cell stiffness regulates Myosin activity and stiffness within the cellular substrate to ultimately promote migration.

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