335 results found
    1. Cell Biology

    A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

    Alberto T Gatta et al.
    A new family of sterol-specific lipid transfer proteins has been found that anchors in the endoplasmic reticulum; some of these proteins stretch across membrane contacts and mediate sterol traffic from the plasma membrane.
    1. Cell Biology
    2. Evolutionary Biology

    Vesicle Coat Proteins: Finding the missing link

    Thomas U Schwartz
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    1. Cell Biology

    Cell Biology: Hopping rim to rim through the Golgi

    Suzanne R Pfeffer
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    1. Cell Biology
    2. Evolutionary Biology

    Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

    Matteo Fumagalli et al.
    Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.
    1. Cell Biology
    2. Plant Biology

    ER assembly of SNARE complexes mediating formation of partitioning membrane in Arabidopsis cytokinesis

    Matthias Karnahl et al.
    SNARE proteins are delivered as complexes already from the endoplasmic reticulum along the secretory pathway to the cell division plane to mediate the formation of the partitioning membrane by vesicle fusion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

    Lars Langemeyer et al.
    Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP-release pathways.
    1. Cell Biology

    The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

    Yingying Zhao et al.
    Ubiquitin ligase adaptors target the selective clearance of misfolded plasma membrane proteins.
    1. Cell Biology
    2. Evolutionary Biology

    Characterization of TSET, an ancient and widespread membrane trafficking complex

    Jennifer Hirst et al.
    A missing link between the AP complexes and COPI sheds light on the evolution of vesicle coat proteins and trafficking pathways in the earliest eukaryotes.
    1. Cell Biology

    A microscopy-based kinetic analysis of yeast vacuolar protein sorting

    Jason C Casler, Benjamin S Glick
    In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
    1. Microbiology and Infectious Disease

    Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis

    Wenqi Yu et al.
    Surface protein precursors traffic to lipoteichoic acid-rich septal membranes of Staphylococcus aureus for cleavage of their YSIRK-GXXS motif signal peptides and SecA-mediated translocation across the plasma membrane.

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