18 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

    Mustafa Mir et al.
    The probability of transcription factors binding to their target sites is choreographed through the formation of dynamic multi-protein hubs that transiently interact with actively transcribing genes.
    1. Physics of Living Systems

    Single molecule microscopy reveals key physical features of repair foci in living cells

    Judith Miné-Hattab et al.
    Upon DNA damage, Rad52 forms a membraneless sub-compartment where Rad52 molecules are highly dynamic and share properties with liquid-liquid phase-separated molecules, reflecting the existence of a liquid droplet around damaged DNA.
    1. Cell Biology

    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates

    Weirui Ma et al.
    Binding of a multivalent RNA-binding protein to mRNAs that are able to form pervasive RNA–RNA interactions induces formation of mesh-like condensates, whereas binding of mostly structured mRNAs induces sphere-like condensates.
    1. Cell Biology
    2. Computational and Systems Biology

    Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

    Taraneh Zarin et al.
    A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Cell Biology
    2. Computational and Systems Biology

    Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

    Tyler S Harmon et al.
    Computational modeling and theoretical analysis reveal how disordered linkers determine whether linear multivalent proteins undergo gelation with or without phase separation.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Pi-Pi contacts are an overlooked protein feature relevant to phase separation

    Robert McCoy Vernon et al.
    Statistics on the frequencies of pi interactions in folded protein structures enable successful prediction of intrinsically disordered protein phase separation, with clear implications for a physical understanding of cellular organization.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The solubility product extends the buffering concept to heterotypic biomolecular condensates

    Aniruddha Chattaraj et al.
    The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster

    Yicheng Luo et al.
    SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that controls the differential expression of identical sequences in the same cell.

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