1,299 results found
    1. Neuroscience

    A theory of working memory without consciousness or sustained activity

    Darinka Trübutschek et al.
    Visual information can be maintained in non-conscious working memory for several seconds via short-term changes in synaptic weights.
    1. Neuroscience

    Distinct neural mechanisms underlie the success, precision, and vividness of episodic memory

    Franziska R Richter et al.
    Combining fMRI with continuous model-based measures of retrieval enables the behavioral and neural dissociation of multiple components of episodic memory.
    1. Neuroscience

    Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease

    John P Grogan et al.
    Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
    1. Neuroscience

    Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop

    Pablo Ripollés et al.
    Self-motivated learning in the absence of external feedback can recruit the same brain network as reward-driven learning.
    1. Neuroscience

    Intrinsically regulated learning is modulated by synaptic dopamine signaling

    Pablo Ripollés et al.
    Dopamine modulates behavioral measures of learning and pleasantness in a learning task guided by intrinsic reward, inducing long-term memory benefits specially in those participants with a high sensitivity to reward.
    1. Neuroscience
    2. Computational and Systems Biology

    Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning

    Rui Ponte Costa et al.
    Combined pre- and postsynaptically expressed long-term plasticity of neuronal connections improves sensory discrimination, and enables rapid relearning of previously encountered information.
    1. Neuroscience

    Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

    Ximena I Salinas-Hernández et al.
    Dopamine signaling is necessary for normal fear extinction learning.
    1. Cell Biology
    2. Neuroscience

    Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin

    Julie Bruyère et al.
    Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
    1. Computational and Systems Biology

    Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species

    Arnaud Belcour et al.
    Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.
    1. Neuroscience

    Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

    Anna J Bowen et al.
    Parabrachial neurons expressing CGRP relay affective components of ascending pain information via distinct thalamic and amygdalar pathways, which together contribute to complementary aspects of adaptive threat responses.

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