Post-menopausal women with atherosclerosis need to take the correct timing for hormone replacement therapy.

Two genome sequencing studies show a consistent association between blood mitochondrial DNA copy number (mtDNAcn) and personality traits and provide support for the hypothesis that mtDNAcn may be a biomarker that connects certain personality characteristics with mortality.

The pulsatile activities of kisspeptin neurons, the central pacemaker activities of reproductive functions, show unexpected robustness in terms of frequency, but a tendency for the intensity to decline, during the transition to reproductive senescence in mice.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.

Younger age at diagnosis of breast cancer was associated with higher risks of incident myocardial infarction and heart failure.

The first-in-class, humanized, epitope-specific FSH-blocking antibody MS-Hu6 is efficacious, durable, and manufacturable, and is therefore poised for further development towards future testing in human trials for osteoporosis, obesity, dyslipidemia and neurodegeneration.

Bilallelic mutations of FANCM, a DNA-damage response gene whose heterozygous mutations predispose to breast cancer, are involved in a familial case of Primary Ovarian Insufficiency establishing a link between infertility and cancer.