116 results found
    1. Cancer Biology

    BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    Harina Vin, Sandra S Ojeda ... Kenneth Y Tsai
    The cancer drug vemurafenib has potent off-target effects on JNK signaling that contribute to the development of squamous cell carcinomas in humans and in mice.

  2. Helping the neighbours: an interview with Meredith Schuman

    Meredith Schuman was born in Minneapolis, Minnesota, USA, and is currently leading a junior research group at the German Center for Integrative Biodiversity Research (iDiv), where she investigates the ecological roles of genes in populations of the wild tobacco plant Nicotiana attenuata. She hopes to find a tenure-track position in molecular chemical ecology when funding for her current position ends in 2017. Her hobbies include reading, writing, running, hiking, bodyweight training and travel, and she loves teaching.
    1. Developmental Biology
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed, Swetha B.M. Gowda ... K VijayRaghavan
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.
    1. Cell Biology
    2. Immunology and Inflammation

    NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

    Sandrine Moutel, Nicolas Bery ... Franck Perez
    A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.

  5. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr, Jacob Basson ... David A Broniatowski
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.

  6. Enabling the Contributor Roles Taxonomy for author contributions

    We are pleased to announce the introduction of the Contributor Roles Taxonomy (CRediT) for author contributions at eLife.

  7. Webinar Report: Advice for new faculty

    How can you handle the challenges involved in setting up your first laboratory?
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Cell Biology
    2. Immunology and Inflammation

    TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

    Andreas Neerincx, Clemens Hermann ... Louise H Boyle
    The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

    Marina Diskowski, Ahmad Reza Mehdipour ... Inga Hänelt
    The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.
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