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    1. Immunology and Inflammation

    Pioneer neutrophils release chromatin within in vivo swarms

    Hannah M Isles, Catherine A Loynes ... Philip M Elks
    Neutrophil swarms form around a single endogenous pioneer neutrophil in vivo, mediated by DNA release from pioneer neutrophils.
    1. Developmental Biology
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed, Swetha B.M. Gowda ... K VijayRaghavan
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.
    1. Cell Biology
    2. Immunology and Inflammation

    TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

    Andreas Neerincx, Clemens Hermann ... Louise H Boyle
    The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

    Marina Diskowski, Ahmad Reza Mehdipour ... Inga Hänelt
    The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.
    1. Cell Biology
    2. Cancer Biology

    Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

    Chelsea U Kidwell, Joseph R Casalini ... Minna Roh-Johnson
    Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and proliferation in response to reactive oxygen species.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Chromatinization of Escherichia coli with archaeal histones

    Maria Rojec, Antoine Hocher ... Tobias Warnecke
    Escherichia coli is surprisingly tolerant to chromatinization by archaeal histones, suggesting that histones can become established as ubiquitous chromatin proteins without interfering critically with some key DNA-templated processes.
    1. Neuroscience

    Normative evidence weighting and accumulation in correlated environments

    Nathan Tardiff, Jiwon Kang, Joshua I Gold
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Nano-scale architecture of blood-brain barrier tight-junctions

    Esther Sasson, Shira Anzi ... Ayal Ben-Zvi
    Super-resolution imaging uncovers sparse occludin vs. clustered ZO1/claudin-5 architecture, and claudin-5 arrangement compacting during blood-brain-barrier tight-junction (TJ) maturation in which TJs become first restrictive to large and later to small molecules.