The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.

Increased Notch signaling enhances germ cell reprograming in C. elegans by antagonizing PRC2-mediated repression, which results in the activation of UTX-1 and other reprograming-promoting genes.

Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.

Nanos is required for germline specification by erasure of maternal program in primordial germ cells.

Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.

The mirror-symmetric structure of the Caenorhabditis elegans gonad is established through the Wnt-independent function of a Frizzled protein and three Wnt proteins with distinct roles.

Multi-level massively parallel reporter assays (H3K27ac, ATAC and short tiles) in a panel of melanoma cell lines, together with a deep learning model, reveal location, multiplicity and grammar of subtype specific enhancers.

259 CpGs associated with season of conception in rural Gambians constitute a valuable resource for investigating epigenetic mechanisms linking early exposures to lifelong health and disease.

AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.

Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.