3,079 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

    Kasper R Andersen et al.
    Components of the nuclear pore complex share structural and functional features with soluble nuclear transport receptors, which suggests that there may be an evolutionary relationship between these two types of protein.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi et al.
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolutionary principles of modular gene regulation in yeasts

    Dawn A Thompson et al.
    The divergence of gene regulation during evolution in yeast traces phylogenetic distance with prominent changes being associated with changes in lifestyle and a whole genome duplication event.
    1. Cell Biology

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo et al.
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Neuroscience

    Dismantling the Papez circuit for memory in rats

    Seralynne D Vann
    In contrast to current models, inputs from midbrain limbic structures, but not from the hippocampus, are necessary for mammillary body contributions to memory.
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Plant Biology

    Transport Proteins: Getting to grips with ammonium

    Yi Wang, Jonathan A Javitch
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    1. Cell Biology
    2. Developmental Biology

    Apical targeting of the formin Diaphanous in Drosophila tubular epithelia

    Tal Rousso et al.
    Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Mari Nishino et al.
    Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

    Stefan Heinrichs et al.
    Reduced expression of MYBL2 contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.

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