Repeated antigen encounters alter the transcriptional state and function of lymph node-resident memory CD8+ T cells to mediate improved immunity against viral infection.
A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
A GPCR activated by the same agonist engages different conformational biosensors at different subcellular locations, suggesting that location-based conformations drive spatial encoding of signaling.
Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
Upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium sponged miR-21–5 p and resulted in upregulation of its target gene, ΔNp63α, which induced transition of EECs to mesenchymal cells.
Providing important data regarding the proportion of COVID-19 vaccine hesitancy and barriers toward vaccination in Arabic-speaking people to guide addressing the problem and achievement of widespread vaccination and collective immunity.
During anaphase B spindle elongation, Klp9 controls the speed of both microtubule sliding and microtubule growth to coordinate the processes and thus maintain spindle stability for faithful chromosome separation.
