In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.

The Saccharomyces cerevisiae spliceosome component Fyv6 contributes to precursor messenger RNA splicing by promoting use of branch site distal 3' splice sites and interacting with key factors involved in exon ligation.