742 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman, Cédric Deluz ... David M Suter
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structural basis of αE-catenin–F-actin catch bond behavior

    Xiao-Ping Xu, Sabine Pokutta ... William I Weis
    A molecular mechanism for force-dependent binding of the cell adhesion proteins αE-catenin and vinculin to actin is derived from the structure of the αE-catenin actin-binding domain bound to F-actin.
    1. Cell Biology
    2. Neuroscience

    Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella

    Liam P. Hallada, Abbas Shirinifard, David J Solecki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

    Cheng-Kuang Huang, Xianbin Yong ... Chwee Teck Lim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

    Erin M Ritchie, Siming Zhong ... Yishi Jin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Ecology
    2. Epidemiology and Global Health

    The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus

    Moritz UG Kraemer, Marianne E Sinka ... Simon I Hay
    The limits to the global distribution of the mosquitoes that transmit dengue and chikungunya have been predicted using a species distribution modelling approach.
    1. Structural Biology and Molecular Biophysics

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera, Chanhyung Bae, Kenton J Swartz
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Probing the force-from-lipid mechanism with synthetic polymers

    Miranda L Jacobs, Jan Steinkühler ... Neha P Kamat
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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