Increased Notch signaling enhances germ cell reprograming in C. elegans by antagonizing PRC2-mediated repression, which results in the activation of UTX-1 and other reprograming-promoting genes.

The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.

Piezo1 exhibits markedly different kinetic behavior in different cellular contexts.

Electron cryo-tomography reveals that bacteria can form structurally-diverse outer membrane extensions with various protein complexes associated with them.

Nanos is required for germline specification by erasure of maternal program in primordial germ cells.

Multi-level massively parallel reporter assays (H3K27ac, ATAC and short tiles) in a panel of melanoma cell lines, together with a deep learning model, reveal location, multiplicity and grammar of subtype specific enhancers.

Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.

Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.

In crystallo observation of HNH family I-PpoI nuclease cleaving DNA suggests that one divalent metal ion and a histidine are required for catalysis.

In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.