β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.