Optogenetic manipulation of BMP signaling indicates that diversity in BMP-dependent gene expression is not well explained by differential responses to BMP, and combinatorial signaling is a major driver of diversity.
Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
The dependence of Nematostella germ cell specification on zygotic Hedgehog pathway activity supports the hypothesis that the eumetazoan common ancestor segregated its germline by inductive signals rather than maternal determinants.
Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.