24 results found
    1. Developmental Biology and Stem Cells

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Gene-free methodology for cell fate dynamics during development

    Francis Corson, Eric D Siggia
    Mathematical methods based on geometry that directly embody the developmental concepts of competency, commitment, and determination provide succinct descriptions of morphogenesis and allow quantitative predictions from fits to sparse genetic data in Caenorhabditis elegans.
    1. Developmental Biology and Stem Cells

    Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

    Jose L Pelliccia et al.
    Genetic analyses demonstrate that Gdf3/Vg1 is a maternal effect gene required for robust Nodal signaling during different phases of embryogenesis including germ-layer formation, Kupffer's vesicle morphogenesis, and left-right patterning.
    1. Developmental Biology and Stem Cells

    Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

    Brent W Bisgrove et al.
    Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.
    1. Developmental Biology and Stem Cells

    Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

    Tessa G Montague, Alexander F Schier
    Nodal is assumed to be the sole inducer of mesendoderm, but the related signal Vg1 is as essential as Nodal in this process.
    1. Developmental Biology and Stem Cells

    Nodal patterning without Lefty inhibitory feedback is functional but fragile

    Katherine W Rogers et al.
    Lefty-mediated feedback inhibition of Nodal signaling mitigates signaling perturbations, but is dispensable for development.
    1. Developmental Biology and Stem Cells

    Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

    Megan L Norris et al.
    Elucidation of direct and indirect roles of GPCR signaling during gastrulation.
    1. Developmental Biology and Stem Cells

    Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

    Stephanie F Bellmaine et al.
    Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum

    Matthias Pechmann et al.
    In the spider Parasteatoda tepidariorum the transcription factor Ets4 is needed for cumulus integrity, dorsoventral patterning and for the activation of hunchback and twist expression.
    1. Developmental Biology and Stem Cells

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.

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