192 results found
    1. Developmental Biology and Stem Cells

    Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells

    Nathan Kumar et al.
    An expandable cell population derived from human pluripotent stem cells exhibits properties of mesoderm and is restricted to differentiate into derivatives of intermediate mesoderm.
    1. Developmental Biology and Stem Cells

    Early patterning and specification of cardiac progenitors in gastrulating mesoderm

    W Patrick Devine et al.
    Multipotent cardiac precursors within a population of mesoderm are rapidly fated to specific anatomic locations in the developing mouse heart.
    1. Developmental Biology and Stem Cells

    Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm

    Elliot A Perens et al.
    The Hand2 transcription factor regulates the dimensions of the kidney by controlling cell fate decisions at the interface between organ fields.
    1. Developmental Biology and Stem Cells

    Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies

    Silvia Urbansky et al.
    Functional recapitulation of a likely evolutionary gain in gene expression shows that two genes are sufficient to switch mesoderm cell internalization from stochastic cell ingression to coordinated epithelial invagination.
    1. Developmental Biology and Stem Cells

    Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis

    Wei Zhao et al.
    Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Cell lineage and cell cycling analyses of the 4d micromere using live imaging in the marine annelid Platynereis dumerilii

    B Duygu Özpolat et al.
    Lineage tracing at single-cell resolution reveals the presence of mesoteloblasts, the embryonic origin of mesodermal growth zone cells, and diverse cell cycling patterns of these lineages in the 'Polychaete' annelid Platynereis.
    1. Developmental Biology and Stem Cells

    Position-dependent plasticity of distinct progenitor types in the primitive streak

    Filip J Wymeersch et al.
    Neuromesodermal and lateral/ventral mesoderm progenitors represent distinct committed states, governed by separate regulatory logics.
    1. Developmental Biology and Stem Cells

    Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

    Megan L Norris et al.
    Elucidation of direct and indirect roles of GPCR signaling during gastrulation.
    1. Developmental Biology and Stem Cells

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Florian Razy-Krajka et al.
    A gene network for heart versus head muscle specification has been identified in the tunicate Ciona.
    1. Developmental Biology and Stem Cells

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
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